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Sphere ‐Induced Rejuvenation of Swine and Human Müller Glia Is Primarily Caused by Telomere Elongation
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Primary swine and human Müller glial cells isolated from the adult retinal tissue and conditioned in vitro suffer a great deal of physical and physiological stresses causing telomere attrition and leading to either cell senescence or death. Sphere suspension culture activates telomere elongation and induces expression of stemness factors not only for rejuvenation of both swine and human Müller cells, but probably also for immortalization of swine Müller cells. At the end, the rejuvenated cells would die of cellular senescence when the entire survival populati...
Source: Stem Cells - January 31, 2017 Category: Stem Cells Authors: Ni Xu, Yao Chen, Kevin C. Dean, Xiaoqin Lu, Xiao Liu, Wei Wang, Douglas C. Dean, Henry J. Kaplan, Ling Gao, Fangtian Dong, Yongqing Liu Tags: Tissue ‐Specific Stem Cells Source Type: research
Adenovirus-mediated transfer of hepatocyte growth factor gene to human dental pulp stem cells under good manufacturing practice improves their potential for periodontal regeneration in swine
Conclusion:
This study indicated that HGF-hDPSCs produced under GMP conditions significantly improved periodontal bone regeneration in swine; thus, this method represents a potential clinical application for periodontal regeneration.
Source: Stem Cell Research and Therapy - December 15, 2015 Category: Stem Cells Authors: Yu CaoZhenhai LiuYilin XieJingchao HuHua WangZhipeng FanChunmei ZhangJingsong WangChu-Tse WuSonglin Wang Source Type: research
Vascular smooth muscle cells derived from inbred swine induced pluripotent stem cells for vascular tissue engineering.
Abstract
Development of autologous tissue-engineered vascular constructs using vascular smooth muscle cells (VSMCs) derived from human induced pluripotent stem cells (iPSCs) holds great potential in treating patients with vascular disease. However, preclinical, large animal iPSC-based cellular and tissue models are required to evaluate safety and efficacy prior to clinical application. Herein, swine iPSC (siPSC) lines were established by introducing doxycycline-inducible reprogramming factors into fetal fibroblasts from a line of inbred Massachusetts General Hospital miniature swine that accept tissue and organ tr...
Source: Biomaterials - September 19, 2017 Category: Materials Science Authors: Luo J, Qin L, Kural MH, Schwan J, Li X, Bartulos O, Cong XQ, Ren Y, Gui L, Li G, Ellis MW, Li P, Kotton DN, Dardik A, Pober JS, Tellides G, Rolle M, Campbell S, Hawley RJ, Sachs DH, Niklason LE, Qyang Y Tags: Biomaterials Source Type: research
Grafted Miniature-Swine Neural Stem Cells of Early Embryonic Mesencephalic Neuroepithelial Origin can Repair the Damaged Neural Circuitry of Parkinson’s Disease Model Rats
Publication date: 21 August 2018Source: Neuroscience, Volume 386Author(s): Yutaka Mine, Toshihiko Momiyama, Takuro Hayashi, Takeshi KawaseAbstractAlthough recent progress in the use of human iPS cell-derived midbrain dopaminergic progenitors is remarkable, alternatives are essential in the strategies of treatment of basal-ganglia-related diseases.Attention has been focused on neural stem cells (NSCs) as one of the possible candidates of donor material for neural transplantation, because of their multipotency and self-renewal characteristics. In the present study, miniature-swine (mini-swine) mesencephalic neuroepithelial s...
Source: Neuroscience - July 5, 2018 Category: Neuroscience Source Type: research
Effect of Rapamycin on mesenchymal stem cells treatment for swine myocardial infarction
Conclusions: Four weeks after MSCs transplantation for curing AMI, the myocardial perfusion and glucose metabolism improved significantly in the Rapamycin group; however, the cardiac function was decreased. It is speculated that Rapamycin might have impacted the effect of MSCs transplantation in infarcted hearts. The mechanism needs further research. Index on SPECT, PET and MRI in Three GroupsControl group MSCs groupRapamycin groupP valueSRS24.43±5.4728.63±3.3420.50±7.70<0.05Defect area (cm2)41.57±12.4844.25±12.8022.50±10.74<0.05SCR12.80±4.9715.33±8.636.20&...
Source: Journal of Nuclear Medicine - May 20, 2019 Category: Nuclear Medicine Authors: Cai, M., Feng, G., Li, L., Zhang, G., Yang, X. Tags: Cardiovascular Basic Science: Metabolism and Molecular Imaging Source Type: research
The evaluation of the safety and efficacy of intravenously administered allogeneic multilineage-differentiating stress-enduring cells in a swine hepatectomy model
ConclusionsAllogeneic Muse cell administration may provide a reparative effect and functional recovery in a 70% hepatectomy swine model and thus may contribute to the treatment of PHLF.
Source: Surgery Today - September 10, 2020 Category: Surgery Source Type: research
Mesenchymal Stem Cells Alleviate Post-resuscitation Cardiac and Cerebral Injuries by Inhibiting Cell Pyroptosis and Ferroptosis in a Swine Model of Cardiac Arrest
Following cardiopulmonary resuscitation (CPR), the ensuing cardiac and cerebral injuries contribute to the poor outcome of cardiac arrest (CA) victims, in which the pathogenetic process is possibly driven by cell pyroptosis and ferroptosis. Mesenchymal stem cells (MSCs) have been shown to be a promising strategy for post-resuscitation cardiac and cerebral protection in rat, but its effectiveness in the clinically relevant swine model and the potential protective mechanism remain unknown. The present study was designed to investigate whether MSCs administration could alleviate post-resuscitation cardiac and cerebral injurie...
Source: Frontiers in Pharmacology - December 9, 2021 Category: Drugs & Pharmacology Source Type: research
Characterization of different in vitro culture conditions to induce a fibro-chondrogenic differentiation of swine adipose-derived stem cells.
Authors: Tessaro I, Di Giancamillo A, Benasciutti E, Nguyen VT, Polito U, Mangiavini L, Peretti GM
Abstract
Meniscus repair is still a challenge for orthopaedic surgeons as this tissue has a scarce healing potential due to the limited vascularization and to the lack of progenitor cells. Lately, several tissue engineering strategies combining cells and scaffolds have been developed. Adipose-derived stem cells (ASCs) represent a novel cell source for meniscus repair as they are easy to harvest, and they possess an intrinsic chondrogenic potential. The aim of our study was to analyze and compare the chondrogenic diffe...
Source: Journal of Biological Regulators and Homeostatic Agents - January 17, 2019 Category: Biomedical Science Tags: J Biol Regul Homeost Agents Source Type: research
Customized 3D-printed occluders enabling the reproduction of consistent and stable heart failure in swine models
AbstractReproducibility of clinical output is important when investigating therapeutic efficacy in pre-clinical animal studies. Due to its physiological relevance, a swine myocardial infarction (MI) model has been widely used to evaluate the effectiveness of stem cells or tissue-engineered constructs for ischemic heart diseases. Several methods are used to induce MI in the swine model. However, it is difficult, using these approaches, to obtain a similar level of functional outcomes from a group of animals due to interpersonal variation, leading to increased experimental cost. Hence, in order to minimize human intervention...
Source: European Journal of Applied Physiology - September 21, 2021 Category: Physiology Source Type: research
Poly (L-Lactic Acid) Cell-Laden Scaffolds Applied on Swine Model of Tracheal Fistula
CONCLUSIONS: PLLA membranes with AT-MSCs attached were useful to the extracellular matrix restoration and have a high potential for small TF treatment. Also, their association with suture filaments enriched with AT-MSCs was advantageous.PMID:35552075 | DOI:10.1016/j.jss.2022.03.024
Source: Cell Research - May 13, 2022 Category: Cytology Authors: Bruna Maria Manzini Jos é Luis Dávila Bruno Bosch Volpe Adriana da Silva Santos Duarte Maria Teresa Ferreira C ôrtez Eliana Aparecida de Rezende Duek Wagner Jos é Fávaro Marcos Akira d' Ávila Ricardo Kalaf Mussi Ângela Cristina Malheiros Luzo Source Type: research
Methods for Transepicardial Cell Transplantation in a Swine Myocardial Infarction Model
Methods Mol Biol. 2022;2485:191-212. doi: 10.1007/978-1-0716-2261-2_13.ABSTRACTThe transplantation of human pluripotent stem cell-derived cardiomyocytes (hPSC-CMs) has garnered significant attention as a potential means of restoring lost muscle mass and contractile function in injured hearts. Early preclinical work with hPSC-CMs employed rodent models, but the field has recently advanced to transplantation studies in more translationally relevant large animal models including non-human primates and swine. The pig is a particularly attractive model for such studies because the size, structure, and physiology of the porcine ...
Source: Mol Biol Cell - May 26, 2022 Category: Molecular Biology Authors: Fanny Wulkan Rocco Romagnuolo Beiping Qiang Michael A Laflamme Source Type: research
Miniature-swine iPSC-derived GABA progenitor cells function in a rat Parkinson's disease model
Cell Tissue Res. 2023 Jan 16. doi: 10.1007/s00441-022-03736-4. Online ahead of print.ABSTRACTInduced pluripotent stem cells (iPS cells) are considered a promising source of cell-based therapy for the treatment of Parkinson's disease (PD). Recent studies have shown forebrain GABA interneurons have crucial roles in many psychiatric disorders, and secondary changes in the GABA system play a directly effect on the pathogenesis of PD. Here, we first describe an efficient differentiation procedure of GABA progenitors (MiPSC-iGABAPs) from miniature-swine iPSCs through two major developmental stages. Then, the MiPSC-iGABAPs were s...
Source: Cell Research - January 16, 2023 Category: Cytology Authors: Yu Guo Huan Zhu Yuanyuan Wang Tingting Sun Jiajia Xu Tie Wang Weijun Guan Chunjing Wang Changqing Liu Caiyun Ma Source Type: research
The compatibility of swine BMDC-derived bile duct endothelial cells with a nanostructured electrospun PLGA material.
Conclusions: BMSCs can be differentiated into the bile duct endothelial cells in vitro. Materials prepared by the electrospinning method have a nanofiber structure, which does not significantly degrade within two weeks. Differentiated cells exhibit good biocompatibility with the nanofibers.
PMID: 23335380 [PubMed - as supplied by publisher]
Source: The International Journal of Artificial Organs - January 18, 2013 Category: Transplant Surgery Authors: Zhou J, Yang AH, Yin X, Xu Y, Cao Y, Xu Q Tags: Int J Artif Organs Source Type: research
